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Proton Pump Inhibitors and Antifungals: How They Interfere with Absorption and Effectiveness
  • By Andy Dargon
  • 28 Jan 2026

Proton Pump Inhibitors and Antifungals: How They Interfere with Absorption and Effectiveness

Proton pump inhibitors can block absorption of some antifungals like itraconazole, making treatments fail. Fluconazole is safe to use with PPIs, but voriconazole needs monitoring. New research even suggests PPIs may boost antifungal power.

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